Levosimendan

Molecular Structure:    
  • Cat. #:    AKA-09
  • Product:    Levosimendan
  • CAS No.:    141505-33-1
  • Molecular Formula:    C14H12N6O
  • Molecular Weight:    280.28468 [g/mol]
  • Chemical Name:    2-[[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
  • Specification:    99%min
  • Packing:    50g/bag; 100g/bag; 500g/bag; 1kg/bag
  • Availability:    In stock
  • OtherName:    Simdax, Levosimedan, levosimendanum, (-)-OR-1259, Simdax (TN), Levosimendan [INN]
    Product References:    

Our Levosimendan is sold as chemical only, not as licensed API; The buyer is reponsible for all the legal and regulatory issues in your own country.

Aktin is soley responsible for the product quality.

Levosimendan is a calcium sensitiser – it increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan exerts its positive inotropic effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner. It also has a vasodilatory effect, by opening adenosine triphosphate (ATP)-sensitive potassium channels in vascular smooth muscle to cause smooth muscle relaxation. The combined inotropic and vasodilatory actions result in an increased force of contraction, decreased preload and decreased afterload. Moreover, by opening also the mitochondrial (ATP)-sensitive potassium channels in cardiomyocytes, the drug exerts a cardioprotective effect.

 
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